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ELOVL5 Promotes the Progression of T-Cell Acute Lymphoblastic Leukemia

ABSTRACT: Acute lymphoblastic leukemia (ALL) represents the most prevalent pediatric malignancy, with acute T-lymphoblastic leukemia (T-ALL) comprising 10-25% of ALL cases. Functional studies revealed that ELOVL5 knockdown inhibited T-ALL cell proliferation and enhanced apoptosis in vitro, while in vivo experiments demonstrated that ELOVL5 suppression resulted in reduced tumor burden and extended survival. RNA-seq analysis was conducted and the differently expressed genes were revealed in the ELOVL5-knockdown J.gamma1 cells in comparison to control group.

ORGANISM(S): Homo sapiens

PROVIDER: GSE292865 | GEO | 2025/12/08

REPOSITORIES: GEO

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