Transcriptomics

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In vivo Perturb-seq uncovers key obstacles to heart repair and regeneration through direct reprogramming


ABSTRACT: We investigated the mechanism underlying Calr suppression-enhanced cardiac reprogramming. As CALR functions as an ER-resident chaperone and Ca2+-binding protein, with Ca2+ acting as a second messenger in fate-determining pathways, particularly cardiogenesis we performed RNA-seq on MGTMyoS-induced MICFs transduced with shCalr or shNT at days 7 and 14 in vitro

ORGANISM(S): Mus musculus

PROVIDER: GSE305453 | GEO | 2026/03/21

REPOSITORIES: GEO

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