The transcriptomic profile of the naïve or CpG-stimulated Rfx7-deficient mouse Follicular B cells and RFX7-transfected lymphoma human cell line U-2932

ABSTRACT: PART 1) Alterations of the transcription factor RFX7 have been reported in different B-cell malignancies. We therefore set out to study the role of RFX7 in B cell activation. So we performed bulk RNA-seq on sorted wild-type or Rfx7-deficient follicular B cells, either naive or activated with CpG. PART 2) RFX7 frameshift and non-sense mutations have been reported in different B-cell malignancies. We therefore set out to study the role of selected truncations in a human lymphoma cell line. We performed bulk RNA-seq on sorted U-2932 cells transfected with different RFX7 encoding constructs.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE308503 | GEO | 2026/04/15

REPOSITORIES: GEO