Lipid-Associated Macrophage Polarization Drives Chronic Xenograft Fibrosis via APOE-SDC2 Signaling

ABSTRACT: Chronic injury of xenografted kidneys, characterized by interstitial fibrosis and tubular atrophy, remains a critical barrier to clinical translation. We employed integrated single-nucleus RNA sequencing, spatial transcriptomics, and plasma proteomics on pig-to-cynomolgus monkey kidney xenografts. We identified lipid-associated macrophage polarization and macrophage-fibroblast crosstalk via APOE-SDC2 signaling as central mechanisms driving fibrosis. Combined immunosuppression suppressed this pathway and prevented injury progression.

ORGANISM(S): Sus scrofa Macaca fascicularis

PROVIDER: GSE311717 | GEO | 2026/05/01

REPOSITORIES: GEO