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Pichinde virus models intrauterine infection by hemorrhagic fever-causing arenaviruses

ABSTRACT: Arenaviruses infection during pregnancy can cause severe maternal disease, congenital infection, and/or fetal demise. Little is known about the pathogenesis of this family of viruses in the placenta because many are endemic in resource-poor regions and must be studied in high containment laboratories. Pichinde virus (PICV) is a nonpathogenic arenavirus that causes hemorrhagic fever-like disease in guinea pigs. In this study, we sought to assess whether PICV replicates in human trophoblasts and how infection affected pregnant guinea pigs. RNA-sequencing was done on PICV-infected human trophoblast stem cells and samples of placenta and decidua collected from infected and control pregnant guinea pigs.

ORGANISM(S): Homo sapiens Cavia porcellus

PROVIDER: GSE329765 | GEO | 2026/09/19

REPOSITORIES: GEO

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