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Expression data of hippocampal neural stem cells from rat

ABSTRACT: Neural stem cells (NSCs) are essential for brain development and adult hippocampal neurogenesis, yet early-life environmental stress may induce persistent dysfunction through epigenetic mechanisms. In this study, we investigated the long-term effects of maternal high-fructose corn syrup (HFCS) intake on NSCs using a rat DOHaD model. Maternal HFCS exposure induced persistent impairments in NSC proliferation and differentiation, accompanied by hippocampus-dependent cognitive dysfunction in offspring. Mechanistically, transient downregulation of Dnmt3a in fetal NSCs was associated with sustained repression of Spp1, encoding intracellular osteopontin (iOPN), a regulator of NSC function. We performed Affymetrix Clariom S microarray analyses of hippocampal NSCs isolated from offspring of control and maternal HFCS-fed rats and identified transcriptomic alterations associated with maternal HFCS exposure.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE332845 | GEO | 2026/07/02

REPOSITORIES: GEO

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