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ScRNAseq of LCMV-specific P14 cells: WT, P2RX7-KO and NKG7-KO

ABSTRACT: We have used Parse Biosciences to generate single-cell RNAseq libraries from P14 CD8+ T cells (wild-type - WT, P2RX7-KO and NKG7-KO) collected from mice infected with either LCMV-Armstrong or LCMV-Clone 13 (days 0, 7 or 30 post-infection). The goal of this study was to determine the transcriptional alterations in memory or exhausted CD8+ T cells driven by the absence of either P2RX7 (a purinergic receptor that senses extracellular ATP) or NKG7 (a metabolic regulator that can downregulate mTORC1 and simultaneously induce cytotoxicity).

ORGANISM(S): Mus musculus

PROVIDER: GSE337539 | GEO | 2026/07/08

REPOSITORIES: GEO

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