The Histone Demethylase KDM6B Restrains Hypermetabolic LYVE1+ Perivascular Macrophages and Preserves Adipogenic Balance [ATAC-seq pvm]
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ABSTRACT: We employed ATAC sequencing to study chromatin accessibility in adipose tissue perivascular macrophages isolated from wild-type and macrophage-specific KDM6B knockout mice fed a high-fat diet for 5 weeks. This study was designed to identify genotype-dependent changes in accessible chromatin regions associated with KDM6B deficiency during early diet-induced obesity. These data provide insights into regulatory elements controlling macrophage identity, inflammatory activation, lipid-associated macrophage states, and immune remodeling in obese adipose tissue.
ORGANISM(S): Mus musculus
PROVIDER: GSE338876 | GEO | 2026/09/01
REPOSITORIES: GEO
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