Transcriptomics,Genomics

Dataset Information

41

Expression data from Treg subsets sorted from healthy human peripheral blood


ABSTRACT: All the sorted Treg cells are gated on CD4+CD25+CD127(low), followed by gating on various subsets using markers indicated in the sample names. All the sorted Teff cells are gated on CD4+CD25-CD127(hi), and further sorted for CD45RO- and CD45RO+ phenotype. Overall design: Each Treg and Teff cell subsets were sorted from three different donors. We sought to identify gene expression signature characteristic to specific Treg subsets

INSTRUMENT(S): [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]

SUBMITTER: Scott Davis 

PROVIDER: GSE64176 | GEO | 2015-10-01

SECONDARY ACCESSION(S): PRJNA270347

REPOSITORIES: GEO

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Publications

Diverse Gene Expression in Human Regulatory T Cell Subsets Uncovers Connection between Regulatory T Cell Genes and Suppressive Function.

Hua Jing J   Davis Scott P SP   Hill Jonathan A JA   Yamagata Tetsuya T  

Journal of immunology (Baltimore, Md. : 1950) 20150914 8


Regulatory T (Treg) cells have a critical role in the control of immunity, and their diverse subpopulations may allow adaptation to different types of immune responses. In this study, we analyzed human Treg cell subpopulations in the peripheral blood by performing genome-wide expression profiling of 40 Treg cell subsets from healthy donors. We found that the human peripheral blood Treg cell population is comprised of five major genomic subgroups, represented by 16 tractable subsets with a partic  ...[more]

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