Transcriptomics,Genomics

Dataset Information

32

Whole Blood Transcriptional Profiling Differentiates Between Asymptomatic and Symptomatic Human Rhinovirus Detection in Children


ABSTRACT: Human rhinoviruses (HRV) are among the most common causes of respiratory infections in humans but can be frequently detected also in asymptomatic subjects. We evaluated the value of gene expression profiles to differentiate asymptomatic detection from symptomatic HRV infection in children. Overall design: Previously healthy children <2 years old (n=151) were enrolled at four study sites (Columbus, OH; Dallas, TX; Turku, Finland; and Malaga, Spain). Children were classified into: HRV- healthy controls (HC; n=37); HRV+ asymptomatic (n=14); HRV+ outpatients (n=30); and HRV+ inpatients (n=70). Whole blood RNA samples were hybridized into Illumina arrays.

INSTRUMENT(S): Illumina HumanHT-12 V3.0 expression beadchip

SUBMITTER: Nicole Baldwin 

PROVIDER: GSE67059 | GEO | 2016-01-14

SECONDARY ACCESSION(S): PRJNA278820

REPOSITORIES: GEO

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Publications

Rhinovirus Detection in Symptomatic and Asymptomatic Children: Value of Host Transcriptome Analysis.

Heinonen Santtu S   Jartti Tuomas T   Garcia Carla C   Oliva Silvia S   Smitherman Cynthia C   Anguiano Esperanza E   de Steenhuijsen Piters Wouter A A WA   Vuorinen Tytti T   Ruuskanen Olli O   Dimo Blerta B   Suarez Nicolas M NM   Pascual Virginia V   Ramilo Octavio O   Mejias Asuncion A  

American journal of respiratory and critical care medicine 20160401 7


Rhinoviruses (RVs) are a major cause of symptomatic respiratory tract infection in all age groups. However, RVs can frequently be detected in asymptomatic individuals.To evaluate the ability of host transcriptional profiling to differentiate between symptomatic RV infection and incidental detection in children.Previously healthy children younger than 2 years old (n = 151) were enrolled at four study sites and classified into four clinical groups: RV- healthy control subjects (n = 37), RV+ asympt  ...[more]

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