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Gene Expression Profiles of 4 CRC PDX models treated by RSPO3 antagonist.

ABSTRACT: RSPO is a WNT pathway activator and functions as a potent regulator of stem cell growth in colon. RSPO family members were produced by several human tumors representing multiple tumor types including ovarian, pancreatic, colon, breast and lung cancer. Specific monoclonal antibody antagonists of RSPO family members were developed. In human patient-derived tumor xenograft models, anti-RSPO treatment markedly inhibited tumor growth either as single agents or in combination with chemotherapy. Furthermore, blockade of RSPO signaling reduced the tumorigenicity of cancer cells based on serial transplantation studies. In order to assess the impact of RSPO3 inhibition and gain insight in the anti-RSPO3 treatment mechanism of action, the global gene expression profiles of 4 human colorectal cancer patient derived models (PDX) were performed using Affymetrix microarray for the xenografts treated by the anti-RSPO3 antibody.

ORGANISM(S): Homo sapiens

PROVIDER: GSE73906 | GEO | 2016/03/03

SECONDARY ACCESSION(S): PRJNA298409

REPOSITORIES: GEO

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Gastric Lgr5+ cells are programmed by Rspo3 to shield the gland from infection

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