Dataset Information


Monocular Visual Deprivation in Macaque Monkeys: A Profile in the Gene Expression of the LGN by LCM

ABSTRACT: Laser capture microdissection was used to obtain individual LGN layers for DNA microarray of Rhesus array in macaque monkeys that Monocular Visual Deprivation was generated by either opaque dark contact lens or tarsoraphoplasty at birth. Keywords: Lateral Geniculate Nucleus, monocular deprivation, Rhesus array, Laser Capture Microdissection, Gene expression Overall design: Lateral Geniculate Nucleus from two months and four months monocular deprived monkey were used. Each Lateral Geniculate Nucleus has deprived parvocellular layers, non-deprived parvocellular layers considered as a replicates.

INSTRUMENT(S): [Rhesus] Affymetrix Rhesus Macaque Genome Array

SUBMITTER: Henry J. Kaminski  

PROVIDER: GSE9795 | GEO | 2008-12-01



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Monocular visual deprivation in macaque monkeys: a profile in the gene expression of lateral geniculate nucleus by laser capture microdissection.

Cheng Georgiana G   Kaminski Henry J HJ   Gong Bendi B   Zhou Lan L   Hatala Denise D   Howell Scott J SJ   Zhou Xiaohua X   Mustari Michael J MJ  

Molecular vision 20080804

Amblyopia is the most common cause of visual impairment in children. Early detection of amblyopia and subsequent intervention are vital in preventing visual loss. Understanding the molecular pathogenesis of amblyopia would greatly facilitate development of therapeutic interventions. An animal model of amblyopia induced by monocular vision deprivation has been extensively studied in terms of anatomic and physiologic alterations that affect visual pathways. However, the molecular events underlying  ...[more]

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