Project description:p130Cas is a polyvalent adapter protein essential for cardiovascular development, and with a key role in cell movement. In order to identify the pathways by which p130Cas exerts its biological functions in endothelial cells we mapped the p130Cas interactome and its dynamic changes in response to VEGF using high-resolution mass spectrometry and reconstruction of protein interaction (PPI) networks with the aid of multiple PPI databases. The work presented here was based on a collaboration between University College London and University College Dublin. Dr Ian Evans (first author) and Prof. Ian Zachary (lab head), can be contacted at: Centre for Cardiovascular Biology and Medicine, Division of Medicine The Rayne Building, University College London, London WC1E 6JJ, United Kingdom. Contact details for University College Dublin collaborators can be found below.
Project description:The study aimed to assess the effect of substituting formic and acetic acids for propionic acid on electrospray ionization and chromatographic performance in reversed-phase LC-MS bottom-up proteomics. The deposit contains LC-MS data acquired at the Faculty of Pharmacy, Charles University, and Biomedical Research Centre, Hradec Králové, Czech Republic. To access the data from other facilities, please refer to the manuscript.
Project description:p130Cas is a polyvalent adapter protein essential for cardiovascular development, and with a key role in cell movement. In order to identify the pathways by which p130Cas exerts its biological functions in endothelial cells we mapped the p130Cas interactome and its dynamic changes in response to VEGF using high-resolution mass spectrometry and reconstruction of protein interaction (PPI) networks with the aid of multiple PPI databases. The work presented here was based on a collaboration between University College London and University College Dublin. Dr Ian Evans (first author) and Prof. Ian Zachary (lab head), can be contacted at: Centre for Cardiovascular Biology and Medicine, Division of Medicine The Rayne Building, University College London, London WC1E 6JJ, United Kingdom. Contact details for University College Dublin collaborators can be found below.
Project description:This Dataset contains files investigating the metabolism of Burkholderia sp. FERM BP-3421. This whole set of data was collected and stored in Eustaquio Lab (the University of Illinois at Chicago - College of Pharmacy) and deposited on GNPS-Massive on 11/03/2022
Project description:In this study we investigated DNA methylation association with Lewy body pathology, profiled genome wide using this Illumina EPIC bead chip array in a set of brain samples sourced from the UK Brain Bank Network from centres at Newcastle, Imperial College London, University College London and Oxford. Data was generated from 779 samples, sourced from 406 unique donors (n = 387 Anterior Cingulate Cortex (ACC), n = 392 Prefrontal Cortex (PFC)). Following quality control, linear modelling approaches were used to assess DNA methylation loci association with Lewy body pathology as measured by the Braak staging criteria. This data was meta analysed alongside two prior established cohorts (Netherlands Brain Bank and Brains for Dementia Research).
Project description:The research was conducted by in-vitro experiments on microglial cells, performed by Wildman lab and Uddin research group in the College of Public Health at the University of the South Florida. The experiments mimic the trauma-related immune environments by utilizing stress hormones. Stress hormones can modify individual internal environment during times of stress, mobilizing energy sources, increasing heart rate, and downregulating metabolic processes
Project description:Sequencing of 16S ribosomal RNA (rRNA) gene, which has improved the characterization of microbial community, has made it possible to detect a low level Helicobacter pylori (HP) sequences even in HP-negative subjects which were determined by a combination of conventional methods. This study was conducted to obtain a cutoff value for HP colonization in gastric mucosa biopsies and gastric juices by the pyrosequencing method. Corresponding author: Nayoung Kim, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, Gyeonggi-do, Korea; Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea (Tel., +82-31-787-7008; e-mail, nayoungkim49@empas.com).
Project description:Qionger He1, Erica D Arroyo2, Samuel N Smukowski3, Jian Xu, Claire Piochon1, Jeffrey N Savas3, Carlos Portera-Cailliau2 and Anis Contractor1,4*
1Department of Physiology & 3Department of Neurology, Northwestern University Feinberg School of Medicine; 2Departments of Neurology and Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 & 4Department of Neurobiology, Weinberg College of Arts and Sciences, Northwestern University, Chicago, IL 60611
Project description:Sex specificity of the C. elegans metabolome
Russell N. Burkhardt1, Alexander B. Artyukhin1,3, Erin Z. Aprison2, Brian J. Curtis1, Bennett W. Fox1, Andreas H. Ludewig1, Amaresh Chaturbedi4, Oishika Panda1, Chester J. J. Wrobel1, Siu S. Lee4, Ilya Ruvinsky2, and Frank C. Schroeder1,
1Boyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States
2Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, United States
3Current address: Chemistry Department, College of Environmental Science and Forestry, State University of New York, Syracuse, New York 13210, United States
4Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, United States
Correspondence to fs31@cornell.edu