Chronic exposure to tramadol induces oxidative damage, inflammation based on mice serum proteome
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: 
Lina Gao
PROVIDER: PXD019233 | iProX | Sat May 16 00:00:00 BST 2020
REPOSITORIES: iProX
Publications
A Proteomics Study on the Mechanism of Nutmeg-Induced Hepatotoxicity.
Xia Wei W Cao Zhipeng Z Zhang Xiaoyu X Gao Lina L
Molecules (Basel, Switzerland) 20210320 6
Nutmeg is a traditional spice and medicinal plant with a variety of pharmacological activities. However, nutmeg abuse due to its hallucinogenic characteristics and poisoning cases are frequently reported. Our previous metabolomics study proved the hepatotoxicity of nutmeg and demonstrated that high-dose nutmeg can affect the synthesis and secretion of bile acids and cause oxidative stress. In order to further investigate the hepatotoxicity of nutmeg, normal saline, 1 g/kg, 4 g/kg nutmeg were adm ...[more]
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