Proteomic profiling reveals the impact of surface functionalization on the protein corona formed on superparamagnetic iron oxide nanoparticles

ABSTRACT: The protein corona formed on the surface of nanomaterials is critical to understanding their biological behavior, as it is regulated by both the physicochemical properties of the nanomaterials and the physiological environment. The interplay between material synthesis characteristics, protein corona composition, and biological fate remains to be fully elucidated. In this project, we investigated the protein corona of six types of 30 nm superparamagnetic iron oxide nanoparticles (IONPs), each coated with dextran and modified with different functional groups (hydroxyl, amine, and carboxyl). Proteomic analysis revealed that nanoparticles with the same surface modifications had similar protein corona compositions, while those with different surface modifications exhibited distinct complement protein profiles. These findings provide a theoretical basis for understanding the immunological responses induced by each nanoparticle type, offering insights into their biological and therapeutic applications.

ORGANISM(S): Homo Sapiens

SUBMITTER: Fangfang Chen  

PROVIDER: PXD056769 | iProX | Mon Oct 14 00:00:00 BST 2024

REPOSITORIES: iProX