Calcium-mediated calreticulin IRE1α interaction drives dynamic fluctuation of IRE1α activity under chronic endoplasmic reticulum stress

ABSTRACT: To investigate the mechanisms underlying fluctuating IRE1α phosphorylation under chronic endoplasmic reticulum stress, we performed co-immunoprecipitation coupled with mass spectrometry (IP-MS) to identify IRE1α-interacting proteins. Protein complexes were analyzed by LC-MS/MS, followed by bioinformatic enrichment analysis to identify candidate regulators of IRE1α phosphorylation and activity.

ORGANISM(S): Homo Sapiens

SUBMITTER: Likun Wang  

PROVIDER: PXD073899 | iProX | Fri Jan 30 00:00:00 GMT 2026

REPOSITORIES: iProX