Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Human colorectal adenomas and cancer

ABSTRACT: human blood plasma proteomes of colorectal adenoma, colorectal cancer and control patients

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Stefan Tenzer (a), Hansjörg Schild (a) and Markus F. Neurath (b)

PROVIDER: PXD007844 | JPOST Repository | Tue Oct 01 00:00:00 BST 2019

REPOSITORIES: jPOST

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	090528_02.raw.zip	Raw
	090528_03.raw.zip	Raw
	090528_04.raw.zip	Raw
	090528_05.raw.zip	Raw
	090528_06.raw.zip	Raw

Items per page:

1 - 5 of 20

Similar Datasets

GNPS - Polar metabolomics of plasma samples in Colorectal Cancer Patients

Project description:large-scale polar metabolomics analysis for plasma sample from colorectal cancer patients

| MSV000092836 | GNPS

HPLC-MS/MS analysis of plasma samples from patients with colorectal cancer

Project description:We sought to identify a characteristic profile of proteins in blood plasma samples taken from patients with colorectal cancer using mass spectrometry. We obtained mass spectrometry data of 38 samples from patients with colorectal cancer and 41 samples from healthy volunteers and the data analysis were carried out using panoramic ultra-high resolution mass spectrometry. We carried out a comparative analysis for two series "case" and "control" of protein profiles, differently expressed proteins and proteins with posttranslational modifications.

2020-04-02 | PXD015163 | Pride

Polar metabolomics of plasma samples in Colorectal Cancer Patients

Project description:large-scale polar metabolomics analysis for plasma sample from colorectal cancer patients

| MSV000092836 | MassIVE

Blood based expression of colorectal cancer and healthy controls

Project description:The immune system is crucial in regulating colorectal cancer tumorigenesis. Identification of immune-related transcriptomic signatures derived from the peripheral blood of colorectal cancer patients will provide insights into colorectal cancer pathogenesis and suggest novel clues to potential colorectal cancer immunotherapy strategies. We used microarrays to detail the blood-based gene expression of colorectal cancer patients and healthy controls to identify the colorectal cancer-specific immune genes potentially diagnostic for colorectal cancer.

2021-01-05 | GSE164191 | GEO

Targeted and Non-targeted Proteomics Data of Human Plasma Extracellular Vesicles in Colorectal Cancer and Healthy Volunteers

Project description:Targeted proteomics data was acquired from plasma extracellular vesicles; two pooled colorectal cancer group and two pooled healthy volunteers group. Non-targeted protemics data (selected reaction monitoring: SRM) was acquired from plasma extracellular vesicles; 209 colorectal cancer patients and 109 healthy volunteers.

2021-03-27 | PXD018228 | JPOST Repository

Tumor-educated circulating monocytes are powerful specific biomarkers for diagnosis of colorectal cancer

Project description:Analysis of tumor-educated changes in peripheral blood monocytes at the gene expression level. We analyzed if gene expression in monocytes of patients with colorectal cancer is differential from those of healthy volunteers and found a diagnostic signature that allowed to accurately discriminate patients with colorectal cancer from healthy individuals. Peripheral blood monocytes from 93 distinct individuals are profiled on 8 beadchips. The individuals belong to one of three groups: healthy volunteers (38), patients with non-metastatic colorectal cancer (27) or patients with metastatic colorectal cancer (28).

2015-04-02 | E-GEOD-47756 | biostudies-arrayexpress

Blood Gene Expression Profiling in Colorectal Cancer

Project description:In this work, we performed gene expression profiling for twenty-paired blood samples collected from healthy controls before and after colonoscopy, and twenty blood samples collected from<br>colorectal cancer patients after colonoscopy. The aim of this study is to determine how significant the colonoscopy procedure may impact the global gene expression in human peripheral blood, and whether this colonoscopy induced variability would bias the biomarker research for colorectal cancer early detection.

2013-10-01 | E-MEXP-3756 | biostudies-arrayexpress

Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening

Project description:MicroRNAs (miRNAs) are small non-coding RNA molecules which function as negative gene regulators. The tissue expression profile of miRNAs shows great promise as a novel biomarker for diagnosis of cancer and other diseases. In addition, some recent reports have demonstrated that are present in human serum and plasma which could make them an ideal non-invasive biomarker for diagnosis of cancer. The aim of this study is to analyze the value/efficacy of the expression profile of plasma miRNAs in differentiating between patients with advanced adenomas and CRC and healthy individuals. The microRNA profiling study comprises serum plasmas from 20 Control, 21 colorectal cancer,20 advanced adenomas.The study also include some samples from patients after treatment.

2013-01-11 | E-GEOD-25609 | biostudies-arrayexpress

Feasibility of unbiased RNA profiling of colorectal tumors: a proof of principle.

Project description:Liquid biopsy profile which can screen for early CRC. We aimed to depict the profile of early stage CRC as well as for advanced adenomas by combination of current molecular knowledge with microarray technology, using efficient circulating free RNA purification from blood and RNA amplification technologies. Circulating free RNA profile of plasma from colorectal cancer patients, advanced adenomas and healthy colonoscopia subjects. Plasma was drawn from 3 healthy colonoscopia subjects, 4 adanced adenomas subjects and 3 colorectal cancer patients. Circulating free RNA was purified from plasma samples and applied on GeneChip human 1.0 ST Arrays. The 'HuGene_1_0_green_yelow_red_DATASET.xlsx' and 'probe_level_expression_matrix.txt' files contain the primary data that was used to draw the conclusions of the current study. Please note that exon-level' analysis was performed but NO probe summarization to probeset was performed, therefore both data matrices contains non-unique identifiers.

2016-06-15 | E-GEOD-83353 | biostudies-arrayexpress

Multi-layered proteomic analysis for colorectal cancer

Project description:Matrix metalloproteinase-2 (MMP-2) plays a role in cell migration and invasion that involve degradation of extracellular matrix proteins as well as vascular remodeling. Increased expression of MMP-2 has often been observed in the tumors of colorectal cancer (CRC) patients. In order to unveil the perturbed proteomic signal during MMP-2-induced cancer progression, we analyzed MMP-2 dependent secretome change in HCT116 cancer cells by stable isotopic labeling with amino acids in cell culture (SILAC), together with the plasma proteome profile of CRC patients by label-free quantification according to disease progression from TNM stage I to IV. We also analyzed public database of CRC tissue proteome deposited by Clinical Proteomic Tumor Analysis Consortium (NCI/NIH). As a strategy for integrating the multi-layered proteomes, we first performed unsupervised hierarchical clustering on plasma and tissue proteomes according to TNM stage, and then Fisher’s exact test to find out which clusters were significantly represented by the secretome decreased by more than 1.5-fold upon MMP-2 knock down. The resultant cluster included CD9-ITGB1-ITGA7 protein complex as well as MMP-2. The proteins included in this cluster were mostly related to cell-cell communications and cell motility, and showed remarkable increased expression in tissue and plasma upon disease progression from TNM I to II. MMP-2 induced activation of FAK phospho-signaling in an activity-dependent manner. With the comparative and integrative multi-layered proteomic analysis, we suggest that high invasiveness featured in the disease progression of colorectal cancer with increased secretion of MMP-2 is because MMP-2 activates FAK signaling through CD9-integrin complex and consequently induces positive feedback of MMP-2 upregulation.

2021-08-26 | PXD018304 | Pride