Understanding the Mechanisms of Asperidine B, a Preussin Derivative, on the Inhibition of Intestinal Cholesterol Absorption Mediated by Tight Junction Function
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ABSTRACT: • Preussin derivatives, asperidine B and its desmethyl analogue, exerted antioxidative and lipid-lowering effects similarly to their parent compound.
• Asperidine B had higher potency by lowering cholesterol level than its methyl analogue in both ex vivo isolated jejunal epithelium, and in vivo models.
• Asperidine B upregulated α-catenin and EpCAM proteins by proteomics approach, which they are relevance in tight junction integrity.
• Asperidine B strongly inhibited intestinal cholesterol absorption by directly interaction with ZO-1 protein function and expression.
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Chutima S. Vaddhanaphuti
PROVIDER: PXD066299 | JPOST Repository | Sat Jul 18 00:00:00 BST 2026
REPOSITORIES: jPOST
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