Proteomics

Dataset Information

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Understanding the Mechanisms of Asperidine B, a Preussin Derivative, on the Inhibition of Intestinal Cholesterol Absorption Mediated by Tight Junction Function


ABSTRACT: • Preussin derivatives, asperidine B and its desmethyl analogue, exerted antioxidative and lipid-lowering effects similarly to their parent compound. • Asperidine B had higher potency by lowering cholesterol level than its methyl analogue in both ex vivo isolated jejunal epithelium, and in vivo models. • Asperidine B upregulated α-catenin and EpCAM proteins by proteomics approach, which they are relevance in tight junction integrity. • Asperidine B strongly inhibited intestinal cholesterol absorption by directly interaction with ZO-1 protein function and expression.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Chutima S. Vaddhanaphuti 

PROVIDER: PXD066299 | JPOST Repository | Sat Jul 18 00:00:00 BST 2026

REPOSITORIES: jPOST

Dataset's files

Source:
Action DRS
Caco2_TP1_1_IDA1.wiff.scan Wiff
Caco2_TP1_1_IDA2.wiff.scan Wiff
Caco2_TP1_1_SWATH1.wiff.scan Wiff
Caco2_TP1_1_SWATH2.wiff.scan Wiff
Caco2_TP1_2_IDA1.wiff.scan Wiff
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