Proteomics

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Secondary-Electrospray Ionization Mass Spectrometry-based Online Analyses of Mouse Volatilome Uncovers Gut Microbiome-Dictated Metabolic Changes in the Host

ABSTRACT: In this study, mouse microbial populations were depleted using an antibiotic cocktail. The microbiome was reestablished using fecal matter transplant or single-strain bacteria species. Volatile organic compounds emitted from the mice were screened to determine if the diversity of the microbial populations can alter host volatilome.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Bacteroides Thetaiotaomicron Escherichia Coli Akkermansia Muciniphila

SUBMITTER: Jiangjiang Zhu  

PROVIDER: MSV000093123 | MassIVE | Mon Oct 16 09:58:00 BST 2023

REPOSITORIES: MassIVE

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Secondary-Electrospray Ionization Mass Spectrometry-Based Online Analyses of Mouse Volatilome Uncover Gut Microbiome-Dictated Metabolic Changes in the Host.

Choueiry Fouad F   Gold Andrew A   Xu Rui R   Zhang Shiqi S   Zhu Jiangjiang J  

Journal of the American Society for Mass Spectrometry 20231127 12

The symbiotic relationship between the gut microbial population is capable of regulating numerous aspects of host physiology, including metabolism. Bacteria can modulate the metabolic processes of the host by feeding on nutritional components within the lumen and releasing bioactive components into circulation. Endogenous volatile organic compound (VOC) synthesis is dependent on the availability of precursors found in mammalian metabolism. Herein, we report that microbial-mediated metabolic infl  ...[more]

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