Phosphoproteomic analysis of legumain deficient mice
Ontology highlight
ABSTRACT: Asparagine endopeptidase (AEP), a cysteine proteinase found in plants and animals, plays a crucial role in regulating kidney homeostasis, immune response, and bone remodelling. It is dysregulated in cancer and neurodegenerative diseases. A study analysing protein phosphorylation in legumain knock-out mice revealed YBX1 phosphorylation on serine 102 as a key site, activating the NF-kB pathway and enhancing inflammation response in the kidney. The study also identified potential novel legumain substrates, providing insights into its role in cellular processes.
INSTRUMENT(S): LTQ Velos
ORGANISM(S): Mus Musculus (ncbitaxon:10090)
SUBMITTER:
Marko Fonovic
PROVIDER: MSV000096338 | MassIVE | Fri Nov 08 00:37:00 GMT 2024
SECONDARY ACCESSION(S): PXD057650
REPOSITORIES: MassIVE
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