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Phosphoproteomic analysis of legumain deficient mice

ABSTRACT: Asparagine endopeptidase (AEP), a cysteine proteinase found in plants and animals, plays a crucial role in regulating kidney homeostasis, immune response, and bone remodelling. It is dysregulated in cancer and neurodegenerative diseases. A study analysing protein phosphorylation in legumain knock-out mice revealed YBX1 phosphorylation on serine 102 as a key site, activating the NF-kB pathway and enhancing inflammation response in the kidney. The study also identified potential novel legumain substrates, providing insights into its role in cellular processes.

INSTRUMENT(S): LTQ Velos

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Marko Fonovic

PROVIDER: MSV000096338 | MassIVE | Fri Nov 08 00:37:00 GMT 2024

SECONDARY ACCESSION(S): PXD057650

REPOSITORIES: MassIVE

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