Dataset Information


Mus musculus

ABSTRACT: Expression data from C2C12 mouse myoblast with treatment actinomycin D

ORGANISM(S): Mus musculus  



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Systematic analysis of cis-elements in unstable mRNAs demonstrates that CUGBP1 is a key regulator of mRNA decay in muscle cells.

Lee Jerome E JE   Lee Ju Youn JY   Wilusz Jeffrey J   Tian Bin B   Wilusz Carol J CJ  

PloS one 20100621 6

<h4>Background</h4>Dramatic changes in gene expression occur in response to extracellular stimuli and during differentiation. Although transcriptional effects are important, alterations in mRNA decay also play a major role in achieving rapid and massive changes in mRNA abundance. Moreover, just as transcription factor activity varies between different cell types, the factors influencing mRNA decay are also cell-type specific.<h4>Principal findings</h4>We have established the rates of decay for o  ...[more]

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