Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Developmental timecourse of mouse ocular lens and whole embryo control

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA147269 | ENA |

REPOSITORIES: ENA

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Publications

iSyTE: integrated Systems Tool for Eye gene discovery.

Lachke Salil A SA   Ho Joshua W K JW   Kryukov Gregory V GV   O'Connell Daniel J DJ   Aboukhalil Anton A   Bulyk Martha L ML   Park Peter J PJ   Maas Richard L RL  

Investigative Ophthalmology & Visual Science 20120321 3


To facilitate the identification of genes associated with cataract and other ocular defects, the authors developed and validated a computational tool termed iSyTE (integrated Systems Tool for Eye gene discovery; http://bioinformatics.udel.edu/Research/iSyTE). iSyTE uses a mouse embryonic lens gene expression data set as a bioinformatics filter to select candidate genes from human or mouse genomic regions implicated in disease and to prioritize them for further mutational and functional analyses.  ...[more]

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