Dataset Information


Mus musculus

ABSTRACT: Granulocyte-monocyte progenitor cell cycle regulation occurs through calcium flux and calcineurin-NFAT signaling via Flt3-L



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Calcium and calcineurin-NFAT signaling regulate granulocyte-monocyte progenitor cell cycle via Flt3-L.

Fric Jan J   Lim Clarice X F CX   Mertes Alexandra A   Lee Bernett T K BT   Viganò Elena E   Chen Jinmiao J   Zolezzi Francesca F   Poidinger Michael M   Larbi Anis A   Strobl Herbert H   Zelante Teresa T   Ricciardi-Castagnoli Paola P  

Stem cells (Dayton, Ohio) 20141201 12

Maintenance of myeloid progenitor cells is controlled by complex regulatory mechanisms and is orchestrated by multiple different transcription factors. Here, we report that the activation of the transcription factor nuclear factor of activated T cells (NFAT) by calcium-sensing protein calcineurin inhibits the proliferation of myeloid granulocyte-monocyte progenitors (GMPs). Myeloid progenitor subtypes exhibit variable sensitivity to induced Ca(2+) entry and consequently display differential enga  ...[more]

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