Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Recurrent 11q aberrations in MYC-neg mature aggressive B-cell lymphomas resembling BL

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA205938 | ENA |

REPOSITORIES: ENA

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Publications

A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma.

Salaverria Itziar I   Martin-Guerrero Idoia I   Wagener Rabea R   Kreuz Markus M   Kohler Christian W CW   Richter Julia J   Pienkowska-Grela Barbara B   Adam Patrick P   Burkhardt Birgit B   Claviez Alexander A   Damm-Welk Christine C   Drexler Hans G HG   Hummel Michael M   Jaffe Elaine S ES   Küppers Ralf R   Lefebvre Christine C   Lisfeld Jasmin J   Löffler Markus M   Macleod Roderick A F RA   Nagel Inga I   Oschlies Ilske I   Rosolowski Maciej M   Russell Robert B RB   Russell Robert B RB   Rymkiewicz Grzegorz G   Schindler Detlev D   Schlesner Matthias M   Scholtysik René R   Schwaenen Carsten C   Spang Rainer R   Szczepanowski Monika M   Trümper Lorenz L   Vater Inga I   Wessendorf Swen S   Klapper Wolfram W   Siebert Reiner R  

Blood 20140107 8


The genetic hallmark of Burkitt lymphoma (BL) is the t(8;14)(q24;q32) and its variants leading to activation of the MYC oncogene. It is a matter of debate whether true BL without MYC translocation exists. Here, we identified 59 lymphomas concordantly called BL by 2 gene expression classifiers among 753 B-cell lymphomas. Only 2 (3%) of these 59 molecular BL lacked a MYC translocation, which both shared a peculiar pattern of chromosome 11q aberration characterized by interstitial gains including 1  ...[more]

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