Dataset Information


Mus musculus

ABSTRACT: Osteotropism in breast cancer metastasis

ORGANISM(S): Mus musculus  



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Identification of prospective factors promoting osteotropism in breast cancer: a potential role for CITED2.

Lau Wen Min WM   Weber Kristy L KL   Doucet Michele M   Chou Yu-Ting YT   Brady Kelly K   Kowalski Jeanne J   Tsai Hua-Ling HL   Yang Justin J   Kominsky Scott L SL  

International journal of cancer 20100201 4

Breast cancer metastases develop in the bone more frequently than any other site and are a common cause of morbidity in the form of bone pain, pathological fractures, nerve compression and life-threatening hypercalcemia. Despite ongoing research efforts, the molecular and cellular mechanisms that regulate breast cancer cell homing to and colonization of the bone as well as resultant pathological bone alteration remain poorly understood. To identify key mediators promoting breast cancer metastasi  ...[more]

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