Dataset Information


Mus musculus

ABSTRACT: Expression data from regenerating mouse TA muscle

ORGANISM(S): Mus musculus  



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Restoration of Functional Glycosylation of α-Dystroglycan in FKRP Mutant Mice Is Associated with Muscle Regeneration.

Awano Hiroyuki H   Blaeser Anthony A   Keramaris Elizabeth E   Xu Lei L   Tucker Jason J   Wu Bo B   Lu Pei P   Lu Qi L QL  

The American journal of pathology 20150512 7

Mutations in fukutin-related protein (FKRP) gene are characterized with lack of functionally glycosylated α-dystroglycan (F-α-DG). Surprisingly, a few muscle fibers express strong F-α-DG. Herein, we investigated the restoration of F-α-DG in the FKRP mutant muscles and showed that the restoration of glycosylation is associated with muscle regeneration and dependent on the expression of both like-glycosyltransferase (LARGE) and partially functional FKRP. F-α-DG in the regenerating fibers reaches u  ...[more]

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