Proteomics

Dataset Information

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Febrile Infant Diagnostic Assessment and Outcome Olink Dataset

ABSTRACT: The FIDO (Febrile Infant Diagnostic assessment and Outcome) study aimed to look at different diagnostic approaches to identify infants with a fever at low and high-risk of serious infection. FIDO was a multicentre prospective observational cohort study that enrolled infants ≤90 days of age presenting with fever to 35 Paediatric Emergency Research in the UK and Ireland (PERUKI) sites. The FIDO study was prospectively registered at ClinicalTrials.gov (NCT05259683; 28 February 2022). Where possible, residual plasma volume was collected and stored from infants for proteomic and biomarker analysis.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Bacterial Sepsis

SUBMITTER: Clare Mills  

LAB HEAD: Clare Mills

PROVIDER: PAD000035 | Pride | 2026-05-29

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
FIDO_Metadata_PRIDE.csv Csv
FIDO_Olink.npx.csv Csv
checksum.txt Txt
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Publications

Applying clinical decision aids for the assessment and management of febrile infants presenting to emergency care in the UK and Ireland: Febrile Infant Diagnostic Assessment and Outcome (FIDO) Study protocol.

Umana Etimbuk E   Mills Clare C   Norman-Bruce Hannah H   Wilson Kathryn K   Mitchell Hannah H   McFetridge Lisa L   Woolfall Kerry K   Lynn Fiona A FA   McKeeman Gareth G   Foster Steven S   Barrett Michael M   Roland Damian D   Lyttle Mark D MD   Watson Chris C   Waterfield Thomas T  

BMJ open 20230920 9

<h4>Introduction</h4>Febrile infants 90 days and younger are at risk of invasive bacterial infections (bacteraemia and meningitis) and urinary tract infections. Together this is previously termed serious bacterial infection with an incidence of approximately 10-20%. The National Institute for Health and Care Excellence guidance advocates a cautious approach with most infants requiring septic screening, parenteral broad-spectrum antibiotics and hospital admission. Internationally, variations exis  ...[more]

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