Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Cell Culture, Fibroblast
DISEASE(S): Disease Free
SUBMITTER: Debbie Cunningham
LAB HEAD: Debbie L Cunningham
PROVIDER: PXD002545 | Pride | 2016-04-15
REPOSITORIES: Pride
Sarhan Adil R AR Patel Trushar R TR Creese Andrew J AJ Tomlinson Michael G MG Hellberg Carina C Heath John K JK Hotchin Neil A NA Cunningham Debbie L DL
Molecular & cellular proteomics : MCP 20160413 6
Intracellular signaling pathways are reliant on protein phosphorylation events that are controlled by a balance of kinase and phosphatase activity. Although kinases have been extensively studied, the role of phosphatases in controlling specific cell signaling pathways has been less so. Leukocyte common antigen-related protein (LAR) is a member of the LAR subfamily of receptor-like protein tyrosine phosphatases (RPTPs). LAR is known to regulate the activity of a number of receptor tyrosine kinase ...[more]