Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Influenza
SUBMITTER: Filip Golebiowski
LAB HEAD: Benjamin Geoffrey Hale
PROVIDER: PXD002943 | Pride | 2015-11-05
REPOSITORIES: Pride
Domingues Patricia P Golebiowski Filip F Tatham Michael H MH Lopes Antonio M AM Taggart Aislynn A Hay Ronald T RT Hale Benjamin G BG
Cell reports 20151105 7
Dynamic nuclear SUMO modifications play essential roles in orchestrating cellular responses to proteotoxic stress, DNA damage, and DNA virus infection. Here, we describe a non-canonical host SUMOylation response to the nuclear-replicating RNA pathogen, influenza virus, and identify viral RNA polymerase activity as a major contributor to SUMO proteome remodeling. Using quantitative proteomics to compare stress-induced SUMOylation responses, we reveal that influenza virus infection triggers unique ...[more]