Proteomics,Multiomics

Dataset Information

0

Peli1 knock-out and wild type mouse brain proteomes during the disease course of experimental autoimmune encephalomyelitis


ABSTRACT: The ubiquitin ligase Peli1 has previously been suggested as a potential treatment target in multiple sclerosis since the knock-out induced less activated microglia and less inflammation in the CNS of experimental autoimmune encephalomyelitis in mice. In the present study the brain proteomes of Peli1 knock-out mice and wild-type mice were analyzed and compared before disease induction and after 10 and 20 days of experimental autoimmune encephalomyelitis using quantitative proteomics. The brain samples were analyzed using TMT labeling of small pools of samples and verified using label-free of individual mice.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

DISEASE(S): Multiple Sclerosis

SUBMITTER: Eystein Oveland  

LAB HEAD: Frode Berven

PROVIDER: PXD003710 | Pride | 2016-09-27

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20150910_Peli1_0-KO1.raw Raw
20150910_Peli1_0-KO2.raw Raw
20150910_Peli1_0-KO3.raw Raw
20150910_Peli1_0-KO4.raw Raw
20150910_Peli1_0-KO5.raw Raw
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