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Phosphoproteomic analysis of Bluetongue virus infection

ABSTRACT: Bluetongue virus causes infections in wild and domesticated ruminants, with the potential for causing significant morbidity, mortality and economic harm in both the developing and developed world. While vaccines have been developed, no treatment for acute infections exists. In this regard, a possible approach is to determine host-cell factors utilised by Bluetongue virus. We thus proceeded to characterize the phosphoproteome of BTV infected HeLa cells to elucidate the intracellular signalling pathways and identify critical host factors activated during Bluetongue virus infection.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell

SUBMITTER: Edward Emmott

LAB HEAD: Polly Roy

PROVIDER: PXD005550 | Pride | 2017-08-29

REPOSITORIES: Pride

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Phosphoproteomic Analysis Reveals the Importance of Kinase Regulation During Orbivirus Infection.

Mohl Bjorn-Patrick BP Emmott Edward E Roy Polly P

Molecular & cellular proteomics : MCP 20170829 11

Bluetongue virus (BTV) causes infections in wild and domesticated ruminants with high morbidity and mortality and is responsible for significant economic losses in both developing and developed countries. BTV serves as a model for the study of other members of the <i>Orbivirus</i> genus. Previously, the importance of casein kinase 2 for BTV replication was demonstrated. To identify intracellular signaling pathways and novel host-cell kinases involved during BTV infection, the phosphoproteome of ...[more]

PMID: 28851738

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