Proteomics

Dataset Information

42

Proteome differences between sporulated oocysts of ToxoDB#9 and Type II Toxoplasma gondii


ABSTRACT: Understanding of protein expression difference in the same stage of T.gondii among different genotypes will facilitate the elucidation of genotypic divergence among the T.gondii strains. A 4-plex iTRAQ (isobaric tag for relative and absolute quantitation) based LC-MS/MS approach was employed to survey the differentially expressed proteins of sporulated oocysts between ToxoDB#1 (PRU) strain and ToxoDB#9 (PYS) strain for the first time.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Toxoplasma gondii  

TISSUE(S): Tissue Not Applicable To Dataset

DISEASE(S): Not Available

SUBMITTER: Ze-Xiang Wang  

LAB HEAD: Xing-Quan Zhu

PROVIDER: PXD005928 | Pride | 2018-10-26

REPOSITORIES: pride

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Publications

Comparative proteomic analysis of virulent and avirulent strains of Toxoplasma gondii reveals strain-specific patterns.

Zhou Dong-Hui DH   Wang Ze-Xiang ZX   Zhou Chun-Xue CX   He Shuai S   Elsheikha Hany M HM   Zhu Xing-Quan XQ  

Oncotarget 20170707 46


Research exploring the proteome of Toxoplasma gondii oocysts has gained momentum over the past few years. However, little is known about the oocyst's protein repertoires that contribute to differential virulence among T. gondii strains. Here, we used isobaric tag for relative and absolute quantitation-based proteomic analysis of oocysts of two T. gondii strains exhibiting the virulent PYS (ToxoDB#9) phenotype versus the less virulent PRU (Type II, ToxoDB#1) phenotype. Our aim was to determine pr  ...[more]

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