Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: Friedel Drepper
LAB HEAD: Prof. Dr. Bettina Warscheid
PROVIDER: PXD007155 | Pride | 2017-11-03
REPOSITORIES: Pride
Naumenko Nataliia N Morgenstern Marcel M Rucktäschel Robert R Warscheid Bettina B Rehling Peter P
Nature communications 20171101 1
The F<sub>1</sub>F<sub>0</sub>-ATP synthase translates a proton flux across the inner mitochondrial membrane into a mechanical rotation, driving anhydride bond formation in the catalytic portion. The complex's membrane-embedded motor forms a proteinaceous channel at the interface between Atp9 ring and Atp6. To prevent unrestricted proton flow dissipating the H<sup>+</sup>-gradient, channel formation is a critical and tightly controlled step during ATP synthase assembly. Here we show that the INA ...[more]