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Aging Twin Population of Human Skeletal Muscle Biopsies

ABSTRACT: Skeletal muscle biopsies from a set of 33 twins (66 individuals), both young and old age.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Skeletal Muscle

SUBMITTER: Evan Williams

LAB HEAD: Kirsi Pietiläinen

PROVIDER: PXD007249 | Pride | 2026-01-23

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	iProphet.pep.xml	Pepxml
	wevan_K170720_SW_001.zip	Other
	wevan_K170720_SW_002.zip	Other
	wevan_K170720_SW_003.zip	Other
	wevan_K170720_SW_004.zip	Other

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Publications

Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI.

van der Kolk Birgitta W BW Saari Sina S Lovric Alen A Arif Muhammad M Alvarez Marcus M Ko Arthur A Miao Zong Z Sahebekhtiari Navid N Muniandy Maheswary M Heinonen Sini S Oghabian Ali A Jokinen Riikka R Jukarainen Sakari S Hakkarainen Antti A Lundbom Jesper J Kuula Juho J Groop Per-Henrik PH Tukiainen Taru T Lundbom Nina N Rissanen Aila A Kaprio Jaakko J Williams Evan G EG Zamboni Nicola N Mardinoglu Adil A Pajukanta Päivi P Pietiläinen Kirsi H KH

Cell reports. Medicine 20210330 4

Tissue-specific mechanisms prompting obesity-related development complications in humans remain unclear. We apply multiomics analyses of subcutaneous adipose tissue and skeletal muscle to examine the effects of acquired obesity among 49 BMI-discordant monozygotic twin pairs. Overall, adipose tissue appears to be more affected by excess body weight than skeletal muscle. In heavier co-twins, we observe a transcriptional pattern of downregulated mitochondrial pathways in both tissues and upregulate ...[more]

PMID: 33948567

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