DNA mismatch repair activity of MutLalpha is regulated by CK2-dependent phosphorylation of MLH1

ABSTRACT: Mass spectrometry based PTM phosphorylation analysis to study regulation mechanism of MUTL alpha, a heterodimer consisting of MLH1 and PMS2 and a key player in DNA mismatch repair (MMR). It could be demonstrated that phosphorylation of MLH1 by Casein Kinase II (CK2) at amino acid position 477 can switch off MMR activity in vitro.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Kidney Cell

DISEASE(S): Colon Cancer

SUBMITTER: Sebastian Funke  

LAB HEAD: Franz H. Grus

PROVIDER: PXD009026 | Pride | 2018-08-29

REPOSITORIES: Pride