Proteomic analysis of liver tissue from a pig model of mutant INS gene induced diabetes of youth (MIDY)

ABSTRACT: To evaluate functional consequences of insulin-deficient diabetes mellitus for the liver, we used a genetically engineered pig model of mutant INS gene induced diabetes of youth (MIDY). Liver samples of MIDY pigs and wild-type (WT) littermate controls were analyzed by label-free proteomics to reveal pathways and key drivers significantly affected by chronic insulin deficiency and hyperglycemia.

INSTRUMENT(S):

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Hepatocyte, Liver

DISEASE(S): Diabetes Mellitus

SUBMITTER: Florian Flenkenthaler  

LAB HEAD: Thomas Fröhlich

PROVIDER: PXD011536 | Pride | 2019-11-12

REPOSITORIES: Pride