Dataset Information


Proteomic analysis of liver tissue from a pig model of mutant INS gene induced diabetes of youth (MIDY)

ABSTRACT: To evaluate functional consequences of insulin-deficient diabetes mellitus for the liver, we used a genetically engineered pig model of mutant INS gene induced diabetes of youth (MIDY). Liver samples of MIDY pigs and wild-type (WT) littermate controls were analyzed by label-free proteomics to reveal pathways and key drivers significantly affected by chronic insulin deficiency and hyperglycemia.


ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Hepatocyte, Liver

DISEASE(S): Diabetes Mellitus

SUBMITTER: Florian Flenkenthaler  

LAB HEAD: Thomas Fröhlich

PROVIDER: PXD011536 | Pride | 2019-11-12


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<h4>Objective</h4>The liver regulates the availability of insulin to other tissues and is the first line insulin response organ physiologically exposed to higher insulin concentrations than the periphery. Basal insulin during fasting inhibits hepatic gluconeogenesis and glycogenolysis, whereas postprandial insulin peaks stimulate glycogen synthesis. The molecular consequences of chronic insulin deficiency for the liver have not been studied systematically.<h4>Methods</h4>We analyzed liver sample  ...[more]

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