Dataset Information
Quantitative proteomic analyses of CD4+ and CD8+ T cells reveals differentially expressed proteins in multiple sclerosis patients and healthy controls
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Culture Condition:cd4+ Cell, Culture Condition:cd8+ Cell
DISEASE(S): Multiple Sclerosis
SUBMITTER: 
Tone Berge
LAB HEAD: Tone Berge
PROVIDER: PXD011785 | Pride | 2019-08-22
REPOSITORIES: Pride
Publications
Quantitative proteomic analyses of CD4<sup>+</sup> and CD8<sup>+</sup> T cells reveal differentially expressed proteins in multiple sclerosis patients and healthy controls.
Clinical proteomics 20190508
<h4>Background</h4>Multiple sclerosis (MS) is an autoimmune, neuroinflammatory disease, with an unclear etiology. However, T cells play a central role in the pathogenesis by crossing the blood-brain-barrier, leading to inflammation of the central nervous system and demyelination of the protective sheath surrounding the nerve fibers. MS has a complex inheritance pattern, and several studies indicate that gene interactions with environmental factors contribute to disease onset.<h4>Methods</h4>In t ...[more]
