Platform independent protein-based cell-of-origin subtyping of diffuse large B-cell lymphoma in formalin-fixed paraffin-embedded tissue
Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 5600
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): B Cell, Primary Cell
DISEASE(S): Lymphoma
SUBMITTER: 
Katharina Limm
LAB HEAD: Prof. Dr. Peter Oefner
PROVIDER: PXD012317 | Pride | 2020-05-18
REPOSITORIES: Pride
Publications
Platform independent protein-based cell-of-origin subtyping of diffuse large B-cell lymphoma in formalin-fixed paraffin-embedded tissue.
Reinders Jörg J Altenbuchinger Michael M Limm Katharina K Schwarzfischer Philipp P Scheidt Tamara T Strasser Lisa L Richter Julia J Szczepanowski Monika M Huber Christian G CG Klapper Wolfram W Spang Rainer R Oefner Peter J PJ
Scientific reports 20200512 1
Diffuse large B-cell lymphoma (DLBCL) is commonly classified by gene expression profiling according to its cell of origin (COO) into activated B-cell (ABC)-like and germinal center B-cell (GCB)-like subgroups. Here we report the application of label-free nano-liquid chromatography - Sequential Window Acquisition of all THeoretical fragment-ion spectra - mass spectrometry (nanoLC-SWATH-MS) to the COO classification of DLBCL in formalin-fixed paraffin-embedded (FFPE) tissue. To generate a protein ...[more]
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