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Proteomics of Human Blood and Semen Exosomes

ABSTRACT: Our analyses uncover enrichment of exosome-based protein signatures specific to blood and semen along with identification of tissue-dependent and -independent perturbations in blood and semen exosomes.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Semen, Blood

SUBMITTER: Siddharth Pratap

LAB HEAD: Siddharth Pratap, PhD

PROVIDER: PXD013033 | Pride | 2019-11-06

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	CVDash_02-18_HumExoHIV_MPIT_Compress.zip	Other
	CVDash_11-17_Hum_MPIT_s11_step-3.zip	Other
	peptides.pep.xml	Pepxml

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Publications

Proteomics Profiling of Autologous Blood and Semen Exosomes from HIV-infected and Uninfected Individuals Reveals Compositional and Functional Variabilities.

Kaddour Hussein H Lyu Yuan Y Welch Jennifer L JL Paromov Victor V Mandape Sammed N SN Sakhare Shruti S SS Pandhare Jui J Stapleton Jack T JT Pratap Siddharth S Dash Chandravanu C Okeoma Chioma M CM

Molecular & cellular proteomics : MCP 20191101 1

Blood and semen are important body-fluids that carry exosomes for bioinformation transmission. Therefore, characterization of their proteomes is necessary for understanding body-fluid-specific physiologic and pathophysiologic functions. Using systematic multifactorial proteomic profiling, we characterized the proteomes of exosomes and exosome-free fractions from autologous blood and semen from three HIV-uninfected and three HIV-infected participants (total of 24 samples). We identified exosome-b ...[more]

PMID: 31676584

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