Dataset Information


Study of the Salmonella enterica strains using the TMT-based proteomics

ABSTRACT: Tandem mass tags were used to performed the multiplexed proteomic study on the Salmonella enterica cell cultures corresponding to various strains of the bacterium.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. SDT1291  

TISSUE(S): Cell Culture

DISEASE(S): Not Available

SUBMITTER: Egor Vorontsov  

LAB HEAD: Joakim Näsvall

PROVIDER: PXD013041 | Pride | 2020-02-26


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Synonymous Mutations in rpsT Lead to Ribosomal Assembly Defects That Can Be Compensated by Mutations in fis and rpoA.

Knöppel Anna A   Andersson Dan I DI   Näsvall Joakim J  

Frontiers in microbiology 20200306

We previously described how four deleterious synonymous mutations in the Salmonella enterica rpsT gene (encoding ribosomal protein S20) result in low S20 levels that can be compensated by mutations that restore [S20]. Here, we have further studied the cause for the deleterious effects of S20 deficiency and found that the S20 mutants were also deficient in four other 30S proteins (S1, S2, S12, and S21), which is likely due to an assembly defect of the S20 deficient 30S subunits. We examined the c  ...[more]

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