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Human Neuron Proteome Altered by Disrupted in schizophrenia 1 (DISC1) Mutations

ABSTRACT: Disrupted in schizophrenia 1 is a protein that is encoded by the DISC1 gene in humans. In coordination with a wide array of interacting partners, DISC1 has been shown to participate in the regulation of cell proliferation, differentiation, migration, neuronal axon and dendrite outgrowth, synapse formation and maturation, synaptic transmission, mitochondrial transport, fission and/or fusion, and cell-to-cell adhesion. Several studies have shown that unregulated expression or altered protein structure of DISC1 may predispose individuals to the development of schizophrenia, major depression, bipolar disorder, and other psychiatric conditions. The cellular functions that are disrupted by permutations in DISC1, which lead to the development of these disorders, have yet to be clearly defined and are the subject of current ongoing research.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain, Neuron Of Cerebral Cortex

DISEASE(S): Schizophrenia

SUBMITTER: xusheng wang

LAB HEAD: Junmin Peng

PROVIDER: PXD013391 | Pride | 2021-09-08

REPOSITORIES: Pride

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Using protein turnover to expand the applications of transcriptomics.

Smail Marissa A MA Reigle James K JK McCullumsmith Robert E RE

Scientific reports 20210223 1

RNA expression and protein abundance are often at odds when measured in parallel, raising questions about the functional implications of transcriptomics data. Here, we present the concept of persistence, which attempts to address this challenge by combining protein half-life data with RNA expression into a single metric that approximates protein abundance. The longer a protein's half-life, the more influence it can have on its surroundings. This data offers a valuable opportunity to gain deeper ...[more]

PMID: 33623108

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