Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: Vytautas Iesmantavicius
LAB HEAD: Heinz Gut
PROVIDER: PXD014119 | Pride | 2019-09-13
REPOSITORIES: Pride
The EMBO journal 20190912 20
In Saccharomyces cerevisiae, the silent information regulator (SIR) proteins Sir2/3/4 form a complex that suppresses transcription in subtelomeric regions and at the homothallic mating-type (HM) loci. Here, we identify a non-canonical BRCA1 C-terminal domain (H-BRCT) in Sir4, which is responsible for tethering telomeres to the nuclear periphery. We show that Sir4 H-BRCT and the closely related Dbf4 H-BRCT serve as selective phospho-epitope recognition domains that bind to a variety of phosphoryl ...[more]