Molecular determinant for MED1 interaction with the VDR-RXR heterodimer

ABSTRACT: To provide structural insights into the mechanism of the specific association of the coactivator MED1 with the Vitamin D nuclear (VDR)-RXR heterodimer, we used combined structural methods including X-ray crystallography, small angle X-ray scattering (SAXS), NMR, hydrogen-deuterium exchange coupled to mass spectrometry (HDX-MS), crosslinking mass spectrometry as well as biophysical methods.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Maxime BOURGUET  

LAB HEAD: Sarah Cianferani

PROVIDER: PXD019530 | Pride | 2021-02-10

REPOSITORIES: Pride