Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Keratinocyte
DISEASE(S): Disease Free
SUBMITTER: Alistair Bailey
LAB HEAD: Paul J Skipp
PROVIDER: PXD021373 | Pride | 2021-01-04
REPOSITORIES: Pride
Toxicological sciences : an official journal of the Society of Toxicology 20210201 1
Skin sensitization following the covalent modification of proteins by low molecular weight chemicals (haptenation) is mediated by cytotoxic T lymphocyte (CTL) recognition of human leukocyte antigen (HLA) molecules presented on the surface of almost all nucleated cells. There exist 3 nonmutually exclusive hypotheses for how haptens mediate CTL recognition: direct stimulation by haptenated peptides, hapten modification of HLA leading to an altered HLA-peptide repertoire, or a hapten altered proteo ...[more]