Proteomic analysis reveals critical immunomolecular mechanisms in macrophage anti-tuberculosis processes

ABSTRACT: Tuberculosis infection activates the autoimmune system. However, the role of autoimmunity after Mycobacterium tuberculosis infection is unclear. In this study, liquid chromatography-tandem mass spectrometry (LC-MS/MS) combined with tandem mass spectrometry (TMT) was used to perform proteomic analysis of five spinal tuberculosis and five protruding disc tissue samples. The identification of key molecular mechanisms provides a molecular target for future treatment of spinal tuberculosis, which may significantly improve patients' quality of life and prognosis.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Intervertebral Disc

SUBMITTER: Xinli Zhan  

LAB HEAD: Xinli Zhan

PROVIDER: PXD022541 | Pride | 2021-01-04

REPOSITORIES: Pride