PLK1 phosphorylation of Epstein-Barr virus nuclear antigen 2

ABSTRACT: The Epstein-Barr virus nuclear antigen 2 (EBNA2) initiates and maintains the proliferation of infected B cells. In search of additional cellular strategies, that control EBNA2 function, we have performed a label-free mass spectrometry-based quantification of cellular proteins in EBNA2 immuno-precipitates and found polo-like kinase 1 (PLK1) to be bound to EBNA2. EBNA2/PLK1 complex formation is strongly enforced by EBNA2 S379 phosphorylation catalyzed by the mitotic CYCLIN B/CDK1 complex.

INSTRUMENT(S):

ORGANISM(S): Human Herpesvirus 4 Strain B95-8

SUBMITTER: Piero Giansanti  

LAB HEAD: Bernhard Kuster

PROVIDER: PXD022970 | Pride | 2021-08-22

REPOSITORIES: Pride