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Identification of proteins that interacted with ESCO2

ABSTRACT: The Flag–ESCO2 plasmids were transfected into HEK293T cells, Flag–ESCO2 complexes were co-immunoprecipitated using an anti-Flag antibody. The Flag–ESCO2 complexes was separated using SDS PAGE, and then was identified by combining silver staining and mass spectrometry.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): T Cell

SUBMITTER: ji-zhong wang

LAB HEAD: huier zhu

PROVIDER: PXD023527 | Pride | 2021-09-10

REPOSITORIES: Pride

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ESCO2 promotes lung adenocarcinoma progression by regulating hnRNPA1 acetylation.

Zhu Hui-Er HE Li Tao T Shi Shengnan S Chen De-Xiong DX Chen Weiping W Chen Hui H

Journal of experimental & clinical cancer research : CR 20210211 1

<h4>Background</h4>Emerging evidence indicates that metabolism reprogramming and abnormal acetylation modification play an important role in lung adenocarcinoma (LUAD) progression, although the mechanism is largely unknown.<h4>Methods</h4>Here, we used three public databases (Oncomine, Gene Expression Omnibus [GEO], The Cancer Genome Atlas [TCGA]) to analyze ESCO2 (establishment of cohesion 1 homolog 2) expression in LUAD. The biological function of ESCO2 was studiedusing cell proliferation, col ...[more]

PMID: 33573689

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