Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF-X
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: WeiQiang Chen
LAB HEAD: Thomas Leonard
PROVIDER: PXD031997 | Pride | 2023-03-11
REPOSITORIES: Pride
Reinhardt Ronja R Hirzel Kai K Link Gisela G Eisler Stephan A SA Hägele Tanja T Parson Matthew A H MAH Burke John E JE Hausser Angelika A Leonard Thomas A TA
Proceedings of the National Academy of Sciences of the United States of America 20230206 7
Phosphorylation is a ubiquitous mechanism by which signals are transduced in cells. Protein kinases, enzymes that catalyze the phosphotransfer reaction are, themselves, often regulated by phosphorylation. Paradoxically, however, a substantial fraction of more than 500 human protein kinases are capable of catalyzing their own activation loop phosphorylation. Commonly, these kinases perform this autophosphorylation reaction in <i>trans</i>, whereby transient dimerization leads to the mutual phosph ...[more]