Proteomics

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Differentially represented proteins in response to tuberculosis identified by quantitative serum proteomics in Asian elephants


ABSTRACT: The study reported here is the first characterization of elephant serum proteome in response to TB. These results advance our understanding of elephant immune response to M. tuberculosis and provide potential biomarkers for diagnosis and control of TB in this endangered species.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Elephas Maximus Maximus

TISSUE(S): Blood Serum

SUBMITTER: Margarita Villar  

LAB HEAD: Margarita Villar

PROVIDER: PXD033830 | Pride | 2022-10-15

REPOSITORIES: Pride

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Publications

Differentially Represented Proteins in Response to Infection with <i>Mycobacterium tuberculosis</i> Identified by Quantitative Serum Proteomics in Asian Elephants.

Villar Margarita M   Rajbhandari Rajesh Man RM   Artigas-Jerónimo Sara S   Contreras Marinela M   Sadaula Amir A   Karmacharya Dibesh D   Alves Paulo Célio PC   Gortázar Christian C   de la Fuente José J  

Pathogens (Basel, Switzerland) 20220903 9


Tuberculosis is a major global concern. Tuberculosis in wildlife is a risk for zoonotic transmission and becoming one of the challenges for conservation globally. In elephants, the number of cases is likely rising. The aim of this study was to identify proteins related to tuberculosis infection in elephants, which could then be used for the development of diagnostic tools and/or vaccines. A serum proteomics approach was used to characterize differentially represented proteins in response to <i>M  ...[more]

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