Dataset Information
Tumor educated macrophages promote neural tissue regeneration and motor recovery following severe spinal cord injury – proteomics data
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Spinal Cord
SUBMITTER: 
Kristin Schubert
LAB HEAD: Kristin Schubert
PROVIDER: PXD038064 | Pride | 2026-01-30
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 20210218_Uniprot_MusMusculus_REFSET_IK.fasta | Fasta | |||
| M2_210_f1.raw | Raw | |||
| M2_210_f2.raw | Raw | |||
| M2_213_f1.raw | Raw | |||
| M2_213_f2.raw | Raw |
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Publications
Tumor-associated macrophages enhance peripheral nerve tumor infiltration and spinal cord repair.
Immunity 20260126 2
Tumor-associated macrophages (TAMs) enhance cancer progression by promoting angiogenesis, extracellular matrix remodeling, and immune suppression. Nerve infiltration also contributes to tumor growth. However, the role of TAMs in promoting intratumoral nerve growth remains unclear. In this study, we have shown that TAMs express a distinct neural growth gene signature. TAMs actively enhanced neural growth within tumors and directly promoted in vitro neurite outgrowth. We identified secreted phosph ...[more]
